Increasingly DMPK departments are involved in the design and analysis of in vivo pharmacology (PKPD) experiments. This course aims to cover the basic concepts of PKPD that will allow scientists to start practising PKPD interpretation. Prior mathematical experience is not required and the objective is not to teach hands on modelling but understanding and interpretation: “what does it mean?”. The course covers a range of topics of linkages between plasma/blood PK and PD, reasons for observing a delay between PK and PD, and the effects of drug tolerance. PKPD knowledge specific to antibodies is also taught. Special emphasis is placed on good design of in vivo PKPD experiments and a systematic approach to understanding trends observed in the data.

Course content includes:

• Direct effects
• Effects with time delay
• PKPD of therapeutic proteins
• Tolerance & feedback models
• Best practice for in vivo experimental design

Intended audience:
The course is for DMPK scientists, and their biology and pharmacology colleagues, who want to learn more about the PKPD and its uses for drug discovery and development.

Schedule:
The course is usually delivered in a face to face format over 3 days (2 night stay).

The course format is a lecture followed by hands-on exercises in small tutor groups. Further discussion of the exercises will be as a whole course group. The hands-on exercises will use example data sets to illustrate the concepts taught in the lectures.

Consistent with the DMDG core principles, the socialising and networking between delegates and with tutors is encouraged at all times including opportunities to connect at coffee breaks, lunchtime and each evening.

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