HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS
ONE-DAY MEETING
REGISTER
 
21 February 2024
Frankfurt, Germany
HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS
ONE-DAY MEETING
REGISTER
 
21 February 2024
Frankfurt, Germany






Introduction
Programme
Terms & Conditions
08.00 - 08.30 Registration, networking, refreshments
08.30 - 09.00 Welcome address
Caroline Rynn (Roche UK) and Heide Duevel (Merck KGaA Darmstadt)
09.00 - 10.30 ADME session 1: Covering multiparameter ADME optimisation of TPDs and practical in vitro & in vivo challenges encountered
Andy Pike (AZ UK), Stefan Steyn (Pfizer US), Ed Hooper-Greenhill (GSK UK)
10.30 - 11.00 Break/networking
11.00 - 12.00 ADME session 2: Covering PBPK of TPDs and novel delivery approaches to target the site of action
Farzaneh Salem (GSK UK), Donglu Zhang (Genentech US)
12.00 - 13.00 Buffet lunch/networking
13.00 - 14.30 PKPD session: Covering PKPD properties of TPDs and application of integrated modeling frameworks to quantitatively predict full in vivo degradation profiles
James Yates (GSK UK), Sofia Guzzetti (AZ UK), Andreas Reichel (Bayer DE)
14.30 - 15.00 Break/networking
15.00 - 15.30 ADME/PKPD round table Q&A
All main presenters
15.30 - 16.30 Spotlight talks: Covering computational frameworks to identify the key drivers of efficacy, a mechanistic PK/PD modeling framework case example, IVIVE of TPD clearance, and prediction of IMHB-mediated PROTAC chameleonicity
Uddipan Sarma (UCB UK), Christine K. Maurer (Merck KGaA Darmstadt), Robin Haid (Bayer DE) and Diego Garcia Jimenez (Uni Turin Italy)
16.30 - 17.00 Meeting highlights and future perspectives
Caroline Rynn (Roche UK) and Heide Duevel (Merck KGaA Darmstadt)
17.00 Meeting closes

DMDG, 9 Cartwright Court, Cartwright Way, Bardon Hill, Leicester, LE67 1UE
Tel: 0116 274 73 52, E: info@dmdg.org
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