Introduction

The Fundamentals of DMPK Course was previously known as the Basic Training Course and has been supporting the industry for nearly 40 years! Always up to date, this course covers a range of topics highlighting the pivotal role played by DMPK throughout the drug discovery and development process. Specific consideration is given to topics as diverse as, in vitro metabolism, pharmacokinetics, quantitative analytical techniques, qualitative detection methodology and isotopic techniques. In addition, consideration is also given to topics which have taken on a greater prevalence in recent years, for example, modelling & simulation techniques and an introduction to the DMPK aspects of large molecules.

The course format includes focussed lectures backed-up by small group tutorials/ interactive workshops, allowing delegates the opportunity to discuss each topic in greater depth. Electronic lecture materials, tutorial questions and model answers will be provided to each delegate. It is hoped that this course will provide an introduction to all aspects of DMPK science, upon which delegates will be able to build through attendance at the DMDG’s other focussed training courses.

Course content includes:

  • Introduction to physicochemical techniques
  • Absorption theory
  • Metabolism fundamentals
  • In vitro techniques
  • Quantitative analytical techniques of extraction, chromatography and detection
  • Introduction to pharmacokinetics
  • Isotopic techniques
  • Development ADME
  • Qualitative detection
  • Introduction to modelling & simulation
  • Introduction to biologics
Intended audience:
This course is intended for new DMPK scientists, or those from other scientific disciplines, who would like a broad introduction to DMPK science.

Schedule:
The course is usually delivered in a face to face format over 3 days (2 night stay). Designed as an interactive course, content is delivered using a combination of lectures and tutorials/ interactive group sessions. Delegates join together as smaller virtual project teams for the tutorials/ interactive workshops. There are 8.5 hours of lectures and 4 hours of tutorials/ interactive workshops.

Consistent with the DMDG core principles, the interactions and networking between delegates and with tutors is encouraged at all times including opportunities to connect at coffee breaks and at dinner each evening.

Tutors:

  • Graeme Scarfe, Sosei Heptares (Course Leader)
  • Melanie Golding, UCB
  • Lee Boyling, Quotient Sciences
  • Mira Wenker, Charles River
  • Lee Goodwin, Labcorp
  • Tim Potter, Cyprotex
  • Matthew Barfield, Roche