Programme
 
Tuesday 22 February 2022
 
12.00 - 13.00 Registration and lunch
13.00 - 13.10 Welcome
Toby Athersuch, Imperial College London, UK and Joint Organising Committee (RSC-BMCS, DMDG, DMG)
13.10 - 14.00 Keynote presentation: Metabolism of strained rings: tales of the unexpected
Martin Hayes, AstraZeneca, SE

Flash poster presentations
14.00 - 14.05 Blood-brain barrier “on-a-chip” model for testing drug permeability into the brain (poster)
Chloë Whitehouse, University of Nottingham, UK
14.05 - 14.10 Presentation title to be confirmed (poster)
Presenter to be confirmed
14.10 - 14.15 Presentation title to be confirmed (poster)
Presenter to be confirmed

DMPK and Drug Discovery I – Chemistry and Mechanisms
14.15 - 14.55 The secret life of acyl glucuronides
Andrew Stachulski, University of Liverpool, UK
14.55 - 15.35 Presentation title to be confirmed
Presenter to be confirmed
 
15.35 - 16.15 Refreshments, exhibition and posters

DMPK and Drug Discovery II – Application and Strategy
16.15 - 16.55 Is drug lipidation a new paradigm in DMPK?
John Sanderson, Durham University, UK
16.55 - 17.35 Presentation title to be confirmed
Presenter to be confirmed
 
17.35 Close
18.00 Drinks reception
19.00 Conference dinner (optional)
22.30 Close
 
Wednesday 23 February 2022
 
Drug Discovery and Drug Safety I – Small Molecules
09.00 - 09.40 Acyl glucuronides in perspective
Ian Wilson, Imperial College London, UK
09.40 - 10.20 The ADME and PKPD profile of an Ion Channel Blocker for a Hot Target
Kevin Beaumont, AstraZeneca, Cambridge, UK
 
10.20 - 10.40 Refreshments, exhibition and posters
 
Drug Discovery and Drug Safety II - Biologics
10.40 - 11.20 Presentation title to be confirmed
Presenter to be confirmed
11.20 - 12.00 Optimising proteolysis targeting chimeras (PROTACs) for oral drug delivery: A drug metabolism and pharmacokinetics perspective
Andy Pike, AstraZeneca Ltd, UK
12.00 - 12.40 Presentation title to be confirmed
Presenter to be confirmed
 
12.40 - 14.00 Lunch, exhibition and posters
 
Analytical and Computational Advances in DMPK
14.00 - 14.40 Prediction of DILI using 3D liver microtissues
Lynsey Chatham, Cyprotex Discovery Ltd, UK
14.40 - 15.20 One-stop metabolite shop: employing multiple tools for accessing drug metabolites
Julia Shanu-Wilson, Hypha Discovery Ltd, UK
15.20 - 16.00 Finding the metabolite needle in a matrix haystack
James O’Neill, Charles River Laboratories, UK
16.00 Closing remarks