Programme
Tuesday 10 November
11.00   Delegate arrival and registration
(lunch between 12.00 - 13.00)
13.00   Course Introduction
Peter Kilford
13.15   Overview Drug Development and Applications of In Vitro Methods
Sandy Baldwin
13.45   Phys Chem Properties
Mark Wenlock
14.30   Phase I Metabolism
Roz Southall
15.15   Coffee
15.45   Phase II
Peter Kilford
16.30   Tutorial 1 - Structures
17.30   Finish
18.30   Dinner and Quiz
 
Wednesday 11 November
09.00   Subcellular Fractions and Hepatocytes - Methods (CLint and phenotyping) and applications
Louise Wray
09.45   Enzyme Kinetics and Clearance Calculations
Peter Kilford
10.30   Coffee
11.00   Tutorial 2 - Kinetics
12.30   Lunch
13.30   Inhibition
Roz Southall
14.15   Induction
Sandy Baldwin
15.00   Coffee
15.30   Tutorial 3 – Inhibition and Induction
17.00   Finish
18.00   Dinner and free evening
 
Thursday 12 November
09.00   Introduction to Transporters
Louise Wray/Rob Elsby
10.00   Coffee
10.30   In vitro methods for Transporters
Rob Elsby
11.30   Tutorial 4 – Transporters Session 1
12.15   Lunch
13.15   Tutorial 4 – Transporters Session 2
14.00   In Silico Modelling
Mark Wenlock/Peter Kilford
15.00   Coffee
15.30   Tutorial 5 – In Silico Models/ Any other questions
17.00   Finish
19.00   Course Dinner
     
Friday 13 November
08.45   Introduction
Peter Kilford
09.00   Tutorial 6 – Case Study
11.45   Summary Tutorial 6
Peter Kilford
12.00   Lunch/Depart