| Thursday 7th March |
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09.30 |
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Arrival, Coffee & Registration
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|
10.00 |
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Introduction
Hugh Walton, Astex Therapeutics Ltd and DMDG Apprentice Committee Member
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10.10 |
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Opening presentation
Rebecca Scott, GSK and DMDG Chair 2018-19
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10.30 |
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First Talks on new in vitro techniques
- Jenny Rankin
- MATEs – Why they are important and how we predict DDIs
- Rosie Rawlinson
- Reactive metabolite trapping: Effects of pH on metabolic activity
- Justine Badee
- Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
- Heather Edwardson
- Development of an Automated Cytosol Stability Assay
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11.40 |
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Refreshments and Posters
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12.00 |
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Cell culture in DMPK
- John Pollard
- A Deterministic Approach to Cell Growth for Increasing Assay Robustness
- Mi-Young Lee
- Understanding biotransformation of slowly cleared chemicals in co-cultured in vitro models, 3D liver Spheroid and HepatoPac
- Katie Haughan
- Developing an In-Vitro Assay to Investigate Endocytosis in the Renal Proximal Tubule
- Elnaz Gozalpour
- Role of human sodium dependent multivitamin transporter in drugs absorption
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13.00 |
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Lunch
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13.45 |
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In vivo study design and LC/MS analysis
- Seshu Tammireddy
- Opportunities and Challenges in Metabolite Identification Studies
- Mykel Evans
- Cinchophen - Understanding the disposition and drug induced liver injury
- Coral Munday
- Developing a Generic Process for the Extraction of Drugs from Blood Samples Dried onto Mitra®
Micro-sampling Devices: Overcoming a New Haematocrit Effect
- Caitlin Lapworth
- An inhaled PK story: How the interplay between physicochemical properties, PK, and formulation
gave rise to small molecules with optimal solubility and lung retention
- Alpesh Shah
- Challenges and considerations to performing a successful in vivo pharmacokinetic study
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15.00 |
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Refreshments and Posters
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15.15 |
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In vivo studies and LC/MS analysis (continued)
- Brett O’Brien
- Development of a rapid LC-MS/MS method for the simultaneous quantification of biomarkers and small
molecule inhibitors in biological matrices
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15.30 |
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Measurement of Compound Binding
- Jenny Baker
- Characterisation of RED devices: A glimpse into the challenges of protein binding in the bioanalysis area of drug development
- Claire Szuster
- Why does urine gobble up my analyte?
- Vanessa Portman
- Optimisation of a high throughput in vitro assay to determine the extent of brain tissue binding and the fraction unbound of potential CNS drugs
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16.15 |
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Poster prize and final viewings
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16.50 |
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Closing remarks
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17.15 -
19.00 |
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Meet up in 'The Eagle' |
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